Publications

[PDF, free access]
A, B, C, D, E, F

Mihaila SM. Drugs Commonly Applied to Kidney Patients May Compromise Renal Tubular Uremic Toxins Excretion. 2020 Toxins (Basel).

[PDF, free access]
A, C, E, G, H, K

Vriend J. Organic anion transporters 1 and 3 influence cellular energy metabolism in renal proximal tubule cells. 2019 Biol Chem.

doi: 10.1515/hsz-2018-0446

[Summary only, paid]
A, G, J

Vriend J. Flow stimulates drug transport in a human kidney proximal tubule-on-a-chip independent of primary cilia. 2019 Biochim Biophys Acta Gen Subj.

[PDF, free access]
A, C, F, G

Van der Made TK et al. Quantitative Translation of Microfluidic Transporter in Vitro Data to in Vivo Reveals Impaired Albumin-Facilitated Indoxyl Sulfate Secretion in Chronic Kidney Disease. 2019 Mol Pharm.

[Summary only, paid]
A, B, E, G, K

Jansen J et al. Remote sensing and signaling in kidney proximal tubules stimulates gut microbiome-derived organic anion secretion. Proc Natl Acad Sci U S A 2019.

[PDF, free access]
A, C, E, G, H, K

Janssen MJ et al. Therapy with 2′-O-Me Phosphorothioate Antisense Oligonucleotides Causes Reversible Proteinuria by Inhibiting Renal Protein Reabsorption. Mol Ther Nucleic Acids. 2019.

[PDF, free access]
A, B, D, E, I

Vriend J et al. Organic anion transporters 1 and 3 influence cellular energy metabolism in renal proximal tubule cells. Biol Chem. 2019.

[Summary only, paid]
A, C, G, J

Sjögren AK et al. A novel multi-parametric high content screening assay in ciPTEC-OAT1 to predict drug-induced nephrotoxicity during drug discovery. Arch Toxicol. 2018.

[Summary only, paid]
A, B, C, D, E

Vormann MK et al. Nephrotoxicity and Kidney Transport Assessment on 3D Perfused Proximal Tubules. AAPS J. 2018.

[PDF, free access]
A, B, C, D, F

Vriend J et al. Screening of Drug-Transporter Interactions in a 3D Microfluidic Renal Proximal Tubule on a Chip. AAPS J. 2018.

doi: 10.1124/dmd.118.080721

[PDF, free access]
A, B, C, D, F

Fedecostante M et al. Recellularized native kidney scaffolds as a novel tool in nephrotoxicity screening. Drug Metab Dispos. 2018.

[PDF, free access]
A, D, G

Nieskens TT et al. Expression of organic anion transporter 1 or 3 in human kidney proximal tubule cells reduces cisplatin sensitivity. Drug Metab Dispos. 2018.

[PDF, free access]
A, B, C,E, G

Mihajlovic M et al. Role of Vitamin D in Maintaining Renal Epithelial Barrier Function in Uremic Conditions. Int J Mol Sci. 2017.

[PDF, free access]
A, G, H, K

Reda A et al. A Human Proximal Tubular Epithelial Cell Model to Explore a Knowledge Gap on Neonatal Drug Disposition. Curr Pharm Des. 2017.

[Summary only, paid]
A, D, E

Caetano-Pinto P. et al. Cetuximab prevents methotrexate-induced cytotoxicity in vitro through epidermal growth factor dependent regulation of renal drug transporters. Mol Pharmaceutics. 2017.

[PDF, free access]
A, C, D, E, G

Jansen J et al. Bioengineered kidney tubules efficiently excrete uremic toxins. Scientific Reports. Sci Rep. 2016.

doi: 10.1021/acs.molpharmaceut.5b00821

[PDF, free access]
A, C, F, K, L

Caetano-Pinto P. et al. Fluorescence based transport assays revisited in a human renal proximal tubule cell line. Mol Pharm. 2016.

[Summary only, paid]
A, C, D

Nieskens TT et al. A Human Renal Proximal Tubule Cell Line with Stable Organic Anion Transporter 1 and 3 Expression Predictive for Antiviral-Induced Toxicity. AAPS J. 2016.

doi: 10.1016/j.tiv.2015.12.009

[PDF, free access]
A, B, C, D, E, H

Gozalpour E. et al. Heterogeneous transport of digitalis-like compounds by P-glycoprotein in vesicular and cellular assays. Toxicol In Vitro 2016.

[Summary only, paid]
A, C

Schophuizen CM et al. Uremic Toxins Induce ET-1 Release by Human Proximal Tubule Cells, which Regulates Organic Cation Uptake Time-Dependently. Cells. 2015.

[PDF, free access]
A, C, G, H, K

Jansen J. et al. Human proximal tubule epithelial cells cultured on hollow fibers: living membranes that actively transport organic cations. Sci Rep. 2015.

[PDF, free access]
A, C, F, K, L

Mutsaers HAM et al. Proximal tubular efflux transporters involved in renal excretion of p-cresyl sulfate and p-cresyl glucuronide: Implications for chronic kidney disease pathophysiology. Toxicol In Vitro. 2015.

doi: 10.1016/j.yexcr.2014.02.011

[Summary only, paid]
A, C, G, H, K

Jansen J et al. A morphological and functional comparison of proximal tubule cell lines established from human urine and kidney tissue. Exp Cell Res. 2014.

[Summary only, paid]
A, C

Schophuizen CMS et al. Cationic uremic toxins affect renal proximal tubule cell functioning through interaction with the organic cation transporter (hOCT2). Pflügers Archives 2013.

[Summary only, paid]
A, C, G, K

Nieskens TT et al. A Human Renal Proximal Tubule Cell Line with Stable Organic Anion Transporter 1 and 3 Expression Predictive for Antiviral-Induced Toxicity. AAPS J. 2016.

doi: 10.1007/s00441-009-0882-y

[PDF, free access]
A, B, C, D, E, H

Wilmer MJ et al., Novel conditionally immortalized human proximal tubule cell line expressing functional influx and efflux transporters. Cell Tissue Res 2010.

[PDF, free access]
A, C, G

B - Biomarkers for toxicity

Vormann MK. Implementation of a human renal proximal tubule on a chip for nephrotoxicity and drug interaction studies. 2021 J Pharm Sci.

[PDF, free access]
A, B, C, D, E, F

Suter-Dick L et al. Combining extracellular miRNA determination with microfluidic 3D-cell cultures for the assessment of nephrotoxicity: A proof-of-concept study. AAPS J 2018.

doi: 10.1016/j.etp.2012.06.002

[PDF, free access]
B, D, E, F

Moghadasali R, et al. Mesenchymal stem cell-conditioned medium accelerates regeneration of human renal proximal tubule epithelial cells after gentamicin toxicity. Exp Toxicol Pathol 2013.

[PDF, free access]
B, D

Van der Made TK et al. Quantitative Translation of Microfluidic Transporter in Vitro Data to in Vivo Reveals Impaired Albumin-Facilitated Indoxyl Sulfate Secretion in Chronic Kidney Disease. 2019 Mol Pharm.

[Summary only, paid]
A, B, E, G, K

Janssen MJ et al. Therapy with 2′-O-Me Phosphorothioate Antisense Oligonucleotides Causes Reversible Proteinuria by Inhibiting Renal Protein Reabsorption. Mol Ther Nucleic Acids. 2019.

[PDF, free access]
A, B, D, E, I

Sjögren AK et al. A novel multi-parametric high content screening assay in ciPTEC-OAT1 to predict drug-induced nephrotoxicity during drug discovery. Arch Toxicol. 2018.

[Summary only, paid]
A, B, C, D, E

Vormann MK et al. Nephrotoxicity and Kidney Transport Assessment on 3D Perfused Proximal Tubules. AAPS J. 2018.

[PDF, free access]
A, B, C, D, F

Vriend J et al. Screening of Drug-Transporter Interactions in a 3D Microfluidic Renal Proximal Tubule on a Chip. AAPS J. 2018.

[PDF, free access]
A, B, C, D, F

Nieskens TT et al. Expression of organic anion transporter 1 or 3 in human kidney proximal tubule cells reduces cisplatin sensitivity. Drug Metab Dispos. 2018.

[PDF, free access]
A, B, C,E, G

C - Drug interaction studies

Vormann MK. Implementation of a human renal proximal tubule on a chip for nephrotoxicity and drug interaction studies. 2021 J Pharm Sci.

doi: 10.3389/fbioe.2020.617364

[PDF, free access]
A, B, C, D, E, F

van Genderen AM .Topographic Guidance in Melt-Electrowritten Tubular Scaffolds Enhances Engineered Kidney Tubule Performance. 2021 Front Bioeng Biotechnol.

[PDF, free access]
C, L

Mihaila SM. Drugs Commonly Applied to Kidney Patients May Compromise Renal Tubular Uremic Toxins Excretion. 2020 Toxins (Basel).

[PDF, free access]
A, C, E, G, H, K

Vriend J. Flow stimulates drug transport in a human kidney proximal tubule-on-a-chip independent of primary cilia. 2019 Biochim Biophys Acta Gen Subj.

[PDF, free access]
A, C, F, G

Jansen J et al. Remote sensing and signaling in kidney proximal tubules stimulates gut microbiome-derived organic anion secretion. Proc Natl Acad Sci U S A 2019.

[PDF, free access]
A, C, E, G, H, K

Vriend J et al. Organic anion transporters 1 and 3 influence cellular energy metabolism in renal proximal tubule cells. Biol Chem. 2019.

[Summary only, paid]
A, C, G, J

Sjögren AK et al. A novel multi-parametric high content screening assay in ciPTEC-OAT1 to predict drug-induced nephrotoxicity during drug discovery. Arch Toxicol. 2018.

[Summary only, paid]
A, B, C, D, E

Vormann MK et al. Nephrotoxicity and Kidney Transport Assessment on 3D Perfused Proximal Tubules. AAPS J. 2018.

[PDF, free access]
A, B, C, D, F

Vriend J et al. Screening of Drug-Transporter Interactions in a 3D Microfluidic Renal Proximal Tubule on a Chip. AAPS J. 2018.

[PDF, free access]
A, B, C, D, F

Nieskens TT et al. Expression of organic anion transporter 1 or 3 in human kidney proximal tubule cells reduces cisplatin sensitivity. Drug Metab Dispos. 2018.

[PDF, free access]
A, B, C,E, G

Mihajlovic M et al. Role of Vitamin D in Maintaining Renal Epithelial Barrier Function in Uremic Conditions. Int J Mol Sci. 2017.

[PDF, free access]
A, G, H, K

Reda A et al. A Human Proximal Tubular Epithelial Cell Model to Explore a Knowledge Gap on Neonatal Drug Disposition. Curr Pharm Des. 2017.

[Summary only, paid]
A, D, E

Caetano-Pinto P. et al. Cetuximab prevents methotrexate-induced cytotoxicity in vitro through epidermal growth factor dependent regulation of renal drug transporters. Mol Pharmaceutics. 2017.

[PDF, free access]
A, C, D, E, G

Jansen J et al. Bioengineered kidney tubules efficiently excrete uremic toxins. Scientific Reports. Sci Rep. 2016.

doi: 10.1021/acs.molpharmaceut.5b00821

[PDF, free access]
A, C, F, K, L

Caetano-Pinto P. et al. Fluorescence based transport assays revisited in a human renal proximal tubule cell line. Mol Pharm. 2016.

[Summary only, paid]
A, C, D

Nieskens TT et al. A Human Renal Proximal Tubule Cell Line with Stable Organic Anion Transporter 1 and 3 Expression Predictive for Antiviral-Induced Toxicity. AAPS J. 2016.

doi: 10.1016/j.tiv.2015.12.009

[PDF, free access]
A, B, C, D, E, H

Gozalpour E. et al. Heterogeneous transport of digitalis-like compounds by P-glycoprotein in vesicular and cellular assays. Toxicol In Vitro 2016.

[Summary only, paid]
A, C

Schophuizen CM et al. Uremic Toxins Induce ET-1 Release by Human Proximal Tubule Cells, which Regulates Organic Cation Uptake Time-Dependently. Cells. 2015.

[PDF, free access]
A, C, G, H, K

Jansen J. et al. Human proximal tubule epithelial cells cultured on hollow fibers: living membranes that actively transport organic cations. Sci Rep. 2015.

[PDF, free access]
A, C, F, K, L

Mutsaers HAM et al. Proximal tubular efflux transporters involved in renal excretion of p-cresyl sulfate and p-cresyl glucuronide: Implications for chronic kidney disease pathophysiology. Toxicol In Vitro. 2015.

doi: 10.1016/j.yexcr.2014.02.011

[Summary only, paid]
A, C, G, H, K

Jansen J et al. A morphological and functional comparison of proximal tubule cell lines established from human urine and kidney tissue. Exp Cell Res. 2014.

[Summary only, paid]
A, C

Schophuizen CMS et al. Cationic uremic toxins affect renal proximal tubule cell functioning through interaction with the organic cation transporter (hOCT2). Pflügers Archives 2013.

doi: 10.1007/s00441-009-0882-y

[Summary only, paid]
A, C, G, K

Wilmer MJ et al., Novel conditionally immortalized human proximal tubule cell line expressing functional influx and efflux transporters. Cell Tissue Res 2010.

[PDF, free access]
A, C, G

Huang J et al. Fluorescently Labeled Cyclodextrin Derivatives as Exogenous Markers for Real-Time Transcutaneous Measurement of Renal Function. Bioconjug Chem. 2016.

doi: 10.1021/acs.bioconjchem.6b00452

[Summary only, paid]
C, D, E

Mutsaers H et al. Uremic toxins inhibit renal metabolic capacity through interference with glucuronidation and mitochondrial respiration. Biochim Biophys Acta 2013.

doi: 10.1016/j.bbadis.2012.09.006

[PDF, free access]
C, G, J, K

D - Drug Screening

Vormann MK. Implementation of a human renal proximal tubule on a chip for nephrotoxicity and drug interaction studies. 2021 J Pharm Sci.

doi:10.1038/s41598-019-51109-9

[PDF, free access]
A, B, C, D, E, F

Abyar, Selda et al. “In vitro nephrotoxicity and anticancer potency of newly synthesized cadmium complexes.” Scientific reports vol. 9,1 14686. 11 Oct. 2019.

[PDF, free access]
D, E, G

Janssen MJ et al. Therapy with 2′-O-Me Phosphorothioate Antisense Oligonucleotides Causes Reversible Proteinuria by Inhibiting Renal Protein Reabsorption. Mol Ther Nucleic Acids. 2019.

[PDF, free access]
A, B, D, E, I

Sjögren AK et al. A novel multi-parametric high content screening assay in ciPTEC-OAT1 to predict drug-induced nephrotoxicity during drug discovery. Arch Toxicol. 2018.

[Summary only, paid]
A, B, C, D, E

Vormann MK et al. Nephrotoxicity and Kidney Transport Assessment on 3D Perfused Proximal Tubules. AAPS J. 2018.

[PDF, free access]
A, B, C, D, F

Vriend J et al. Screening of Drug-Transporter Interactions in a 3D Microfluidic Renal Proximal Tubule on a Chip. AAPS J. 2018.

doi: 10.1124/dmd.118.080721

[PDF, free access]
A, B, C, D, F

Fedecostante M et al. Recellularized native kidney scaffolds as a novel tool in nephrotoxicity screening. Drug Metab Dispos. 2018.

[PDF, free access]
A, D, G

Reda A et al. A Human Proximal Tubular Epithelial Cell Model to Explore a Knowledge Gap on Neonatal Drug Disposition. Curr Pharm Des. 2017.

[Summary only, paid]
A, D, E

Caetano-Pinto P. et al. Cetuximab prevents methotrexate-induced cytotoxicity in vitro through epidermal growth factor dependent regulation of renal drug transporters. Mol Pharmaceutics. 2017.

doi: 10.1021/acs.molpharmaceut.5b00821

[PDF, free access]
A, C, D, E, G

Caetano-Pinto P. et al. Fluorescence based transport assays revisited in a human renal proximal tubule cell line. Mol Pharm. 2016.

[Summary only, paid]
A, C, D

Nieskens TT et al. A Human Renal Proximal Tubule Cell Line with Stable Organic Anion Transporter 1 and 3 Expression Predictive for Antiviral-Induced Toxicity. AAPS J. 2016.

[PDF, free access]
A, B, C, D, E, H

Nieskens TT et al. A Human Renal Proximal Tubule Cell Line with Stable Organic Anion Transporter 1 and 3 Expression Predictive for Antiviral-Induced Toxicity. AAPS J. 2016.

[PDF, free access]
A, B, C, D, E, H

De Leo E. Cell-Based Phenotypic Drug Screening Identifies Luteolin as Candidate Therapeutic for Nephropathic Cystinosis. 2020. J Am Soc Nephrol. 2020.

[Summary only, paid]
D, E, G, H, I

Suter-Dick L et al. Combining extracellular miRNA determination with microfluidic 3D-cell cultures for the assessment of nephrotoxicity: A proof-of-concept study. AAPS J 2018.

doi: 10.1021/acs.bioconjchem.6b00452

[PDF, free access]
B, D, E, F

Huang J et al. Fluorescently Labeled Cyclodextrin Derivatives as Exogenous Markers for Real-Time Transcutaneous Measurement of Renal Function. Bioconjug Chem. 2016.

[Summary only, paid]
C, D, E

Mekahli D et al. Polycystin-1 but not polycystin-2 deficiency causes upregulation of the mTOR pathway and can be synergistically targeted with rapamycin and metformin. Pflugers Arch. 2014.

doi: 10.1007/s00424-013-1394-x

[Summary only, paid]
D, E, G, H

Moghadasali R, et al. Mesenchymal stem cell-conditioned medium accelerates regeneration of human renal proximal tubule epithelial cells after gentamicin toxicity. Exp Toxicol Pathol 2013.

doi: 10.1016/j.etp.2012.06.002

[PDF, free access]
B, D

E - Drug development and mechanistic studies

Vormann MK. Implementation of a human renal proximal tubule on a chip for nephrotoxicity and drug interaction studies. 2021 J Pharm Sci.

doi:10.1038/s41598-019-51109-9

[PDF, free access]
A, B, C, D, E, F

Abyar, Selda et al. “In vitro nephrotoxicity and anticancer potency of newly synthesized cadmium complexes.” Scientific reports vol. 9,1 14686. 11 Oct. 2019.

[PDF, free access]
D, E, G

Mihaila SM. Drugs Commonly Applied to Kidney Patients May Compromise Renal Tubular Uremic Toxins Excretion. 2020 Toxins (Basel).

[PDF, free access]
A, C, E, G, H, K

Van der Made TK et al. Quantitative Translation of Microfluidic Transporter in Vitro Data to in Vivo Reveals Impaired Albumin-Facilitated Indoxyl Sulfate Secretion in Chronic Kidney Disease. 2019 Mol Pharm.

[Summary only, paid]
A, B, E, G, K

Jansen J et al. Remote sensing and signaling in kidney proximal tubules stimulates gut microbiome-derived organic anion secretion. Proc Natl Acad Sci U S A 2019.

[PDF, free access]
A, C, E, G, H, K

Janssen MJ et al. Therapy with 2′-O-Me Phosphorothioate Antisense Oligonucleotides Causes Reversible Proteinuria by Inhibiting Renal Protein Reabsorption. Mol Ther Nucleic Acids. 2019.

[PDF, free access]
A, B, D, E, I

Sjögren AK et al. A novel multi-parametric high content screening assay in ciPTEC-OAT1 to predict drug-induced nephrotoxicity during drug discovery. Arch Toxicol. 2018.

[Summary only, paid]
A, B, C, D, E

Nieskens TT et al. Expression of organic anion transporter 1 or 3 in human kidney proximal tubule cells reduces cisplatin sensitivity. Drug Metab Dispos. 2018.

[PDF, free access]
A, B, C,E, G

Reda A et al. A Human Proximal Tubular Epithelial Cell Model to Explore a Knowledge Gap on Neonatal Drug Disposition. Curr Pharm Des. 2017.

[Summary only, paid]
A, D, E

Caetano-Pinto P. et al. Cetuximab prevents methotrexate-induced cytotoxicity in vitro through epidermal growth factor dependent regulation of renal drug transporters. Mol Pharmaceutics. 2017.

[PDF, free access]
A, C, D, E, G

Nieskens TT et al. A Human Renal Proximal Tubule Cell Line with Stable Organic Anion Transporter 1 and 3 Expression Predictive for Antiviral-Induced Toxicity. AAPS J. 2016.

[PDF, free access]
A, B, C, D, E, H

Nieskens TT et al. A Human Renal Proximal Tubule Cell Line with Stable Organic Anion Transporter 1 and 3 Expression Predictive for Antiviral-Induced Toxicity. AAPS J. 2016.

doi: 10.1007/s10637-020-00970-x

[PDF, free access]
A, B, C, D, E, H

Rood JJM. Extrahepatic metabolism of ibrutinib. 2020 Invest New Drugs.

[PDF, free access]
E, G, J

De Leo E. Cell-Based Phenotypic Drug Screening Identifies Luteolin as Candidate Therapeutic for Nephropathic Cystinosis. 2020. J Am Soc Nephrol. 2020.

doi: 10.1161/HYPERTENSIONAHA.120.14845

[Summary only, paid]
D, E, G, H, I

Sun Y. Megalin: A Novel Endocytic Receptor for Prorenin and Renin. 2020 Hypertension.

[PDF, free access]
E, G, I

S. Abyar et al. In vitro nephrotoxicity and anticancer potency of newly synthesized cadmium complexes. Sci Reports. 2019.

doi: 10.1038/s41598-019-51109-9

[PDF, free access]
B, D, E

Suter-Dick L et al. Combining extracellular miRNA determination with microfluidic 3D-cell cultures for the assessment of nephrotoxicity: A proof-of-concept study. AAPS J 2018.

[PDF, free access]
B, D, E, F

Schirris TJJet al. Mild intracellular acidification by dexamethasone attenuates mitochondrial dysfunction in a human inflammatory proximal tubule epithelial cell model. Sci Rep. 2017.

doi: 10.1016/j.ejphar.2016.12.034

[PDF, free access]
E, G, H, J

Peters E et al. Effects of a human recombinant alkaline phosphatase during impaired mitochondrial function in human renal proximal tubule epithelial cells. Eur J Pharmacol. 2017.

[Summary only, paid]
E, J

Huang J et al. Fluorescently Labeled Cyclodextrin Derivatives as Exogenous Markers for Real-Time Transcutaneous Measurement of Renal Function. Bioconjug Chem. 2016

doi: 10.1021/acs.bioconjchem.6b00452

[Summary only, paid]
C, D, E

Peters E et al. Alkaline phosphatase protects against renal inflammation through dephosphorylation of lipopolysaccharide and adenosine triphosphate. Br J Pharmacol. 2015.

[PDF, free access]
E, G, H, J

F - Kidney on a chip and microfluidics

Vormann MK. Implementation of a human renal proximal tubule on a chip for nephrotoxicity and drug interaction studies. 2021 J Pharm Sci.

[PDF, free access]
A, B, C, D, E, F

Suter-Dick L et al. Combining extracellular miRNA determination with microfluidic 3D-cell cultures for the assessment of nephrotoxicity: A proof-of-concept study. AAPS J 2018.

[PDF, free access]
B, D, E, F

Vriend J. Flow stimulates drug transport in a human kidney proximal tubule-on-a-chip independent of primary cilia. 2019 Biochim Biophys Acta Gen Subj.

[PDF, free access]
A, C, F, G

Vormann MK et al. Nephrotoxicity and Kidney Transport Assessment on 3D Perfused Proximal Tubules. AAPS J. 2018.

[PDF, free access]
A, B, C, D, F

Vriend J et al. Screening of Drug-Transporter Interactions in a 3D Microfluidic Renal Proximal Tubule on a Chip. AAPS J. 2018.

[PDF, free access]
A, B, C, D, F

Jansen J et al. Bioengineered kidney tubules efficiently excrete uremic toxins. Scientific Reports. Sci Rep. 2016.

[PDF, free access]
A, C, F, K, L

Jansen J. et al. Human proximal tubule epithelial cells cultured on hollow fibers: living membranes that actively transport organic cations. Sci Rep. 2015.

doi: 10.1002/mabi.201800412

[PDF, free access]
A, C, F, K, L

Jansen K et al., Fabrication of Kidney Proximal Tubule Grafts Using Biofunctionalized Electrospun Polymer Scaffolds. Macromol Biosci. 2018.

[PDF, free access]
F, L

Jansen, Katja et al. “Spinach and Chive for Kidney Tubule Engineering: the Limitations of Decellularized Plant Scaffolds and Vasculature.” The AAPS journal vol. 23,1 11. 28 Dec. 2020.

doi:10.1208/s12248-020-00550-0

[PDF, free access]
F, L

Schophuizen CM et al. Development of a living membrane comprising a functional human renal proximal tubule cell monolayer on polyethersulfone polymeric membrane. Acta Biomater. 2015.

doi: 10.1016/j.actbio.2014

[Summary only, paid]
F, L

G - Renal Physiology & Pathology

Abyar, Selda et al. “In vitro nephrotoxicity and anticancer potency of newly synthesized cadmium complexes.” Scientific reports vol. 9,1 14686. 11 Oct. 2019.

doi:10.1038/s41598-019-51109-9

[PDF, free access]
D, E, G

Mihaila SM. Drugs Commonly Applied to Kidney Patients May Compromise Renal Tubular Uremic Toxins Excretion. 2020 Toxins (Basel).

[PDF, free access]
A, C, E, G, H, K

Mutsaers H et al. Uremic toxins inhibit renal metabolic capacity through interference with glucuronidation and mitochondrial respiration. Biochim Biophys Acta 2013.

doi: 10.1016/j.bbadis.2012.09.006

[PDF, free access]
C, G, J, K

De Leo E. Cell-Based Phenotypic Drug Screening Identifies Luteolin as Candidate Therapeutic for Nephropathic Cystinosis. 2020. J Am Soc Nephrol. 2020.

doi: 10.1007/s00424-013-1394-x

[Summary only, paid]
D, E, G, H, I

Mekahli D et al. Polycystin-1 but not polycystin-2 deficiency causes upregulation of the mTOR pathway and can be synergistically targeted with rapamycin and metformin. Pflugers Arch. 2014.

[Summary only, paid]
D, E, G, H

Vriend J. Organic anion transporters 1 and 3 influence cellular energy metabolism in renal proximal tubule cells. 2019 Biol Chem.

doi: 10.1515/hsz-2018-0446

[Summary only, paid]
A, G, J

Vriend J. Flow stimulates drug transport in a human kidney proximal tubule-on-a-chip independent of primary cilia. 2019 Biochim Biophys Acta Gen Subj.

[PDF, free access]
A, C, F, G

Van der Made TK et al. Quantitative Translation of Microfluidic Transporter in Vitro Data to in Vivo Reveals Impaired Albumin-Facilitated Indoxyl Sulfate Secretion in Chronic Kidney Disease. 2019 Mol Pharm.

[Summary only, paid]
A, B, E, G, K

Jansen J et al. Remote sensing and signaling in kidney proximal tubules stimulates gut microbiome-derived organic anion secretion. Proc Natl Acad Sci U S A 2019.

[PDF, free access]
A, C, E, G, H, K

Vriend J et al. Organic anion transporters 1 and 3 influence cellular energy metabolism in renal proximal tubule cells. Biol Chem. 2019.

doi: 10.1124/dmd.118.080721

[Summary only, paid]
A, C, G, J

Fedecostante M et al. Recellularized native kidney scaffolds as a novel tool in nephrotoxicity screening. Drug Metab Dispos. 2018.

[PDF, free access]
A, D, G

Nieskens TT et al. Expression of organic anion transporter 1 or 3 in human kidney proximal tubule cells reduces cisplatin sensitivity. Drug Metab Dispos. 2018.

[PDF, free access]
A, B, C,E, G

Mihajlovic M et al. Role of Vitamin D in Maintaining Renal Epithelial Barrier Function in Uremic Conditions. Int J Mol Sci. 2017.

[PDF, free access]
A, G, H, K

Caetano-Pinto P. et al. Cetuximab prevents methotrexate-induced cytotoxicity in vitro through epidermal growth factor dependent regulation of renal drug transporters. Mol Pharmaceutics. 2017.

[PDF, free access]
A, C, D, E, G

Schophuizen CM et al. Uremic Toxins Induce ET-1 Release by Human Proximal Tubule Cells, which Regulates Organic Cation Uptake Time-Dependently. Cells. 2015.

[PDF, free access]
A, C, G, H, K

Mutsaers HAM et al. Proximal tubular efflux transporters involved in renal excretion of p-cresyl sulfate and p-cresyl glucuronide: Implications for chronic kidney disease pathophysiology. Toxicol In Vitro. 2015.

[Summary only, paid]
A, C, G, H, K

Schophuizen CMS et al. Cationic uremic toxins affect renal proximal tubule cell functioning through interaction with the organic cation transporter (hOCT2). Pflügers Archives 2013.

doi: 10.1007/s00441-009-0882-y

[Summary only, paid]
A, C, G, K

Wilmer MJ et al., Novel conditionally immortalized human proximal tubule cell line expressing functional influx and efflux transporters. Cell Tissue Res 2010.

[PDF, free access]
A, C, G

Rood JJM. Extrahepatic metabolism of ibrutinib. 2020 Invest New Drugs.

doi: 10.1007/s10637-020-00970-x

[PDF, free access]
E, G, J

Sun Y. Megalin: A Novel Endocytic Receptor for Prorenin and Renin. 2020 Hypertension.

doi: 10.1161/HYPERTENSIONAHA.120.14845

[PDF, free access]
E, G, I

Di Mise A et al. Activation of the Calcium-Sensing Receptor Corrects the Impaired Mitochondrial Energy Status Observed in Renal Polycystin-1 Knockdown Cells Modeling Autosomal Dominant Polycystic Kidney Disease. Front Mol Biosci. 2018.

doi: 10.3389/fmolb.2018.00077

[PDF, free access]
G, H, J

Raaij, van SEG et al. Inhibition of Nrf2 alters cell stress induced by chronic iron exposure in human proximal tubular epithelial cells. Toxicol Lett. 2018.

doi: 10.1016/j.toxlet.2018.06.1218

[Summary only, paid]
G, H, J

Chevtchik NV et al. A bioartificial kidney device with polarized secretion of immune modulators. J Tissue Eng Regen Med. 2018.

doi:10.1002/term.2694

[Summary only, paid]
G, L

Di Mise A et al. Activation of Calcium-Sensing Receptor increases intracellular calcium and decreases cAMP and mTOR in PKD1 deficient cells. Sci Rep. 2018.

doi: 10.1038/s41598-018-23732-5

[PDF, free access]
G, H

Jamalpoor A et al. Quantification of cystine in human renal proximal tubule cells using liquid chromatography-tandem mass spectrometry. Biomed Chromatogr. 2018.

doi: 10.1002/bmc.4238

[PDF, free access]
G, H, I

Weber HM et al. Heparin-based hydrogels induce human renal tubulogenesis in vitro. Acta Biomater. 2017.

doi: 10.1016/j.actbio.2017.05.035

[Summary only, paid]
G, H, L

Schirris TJJet al. Mild intracellular acidification by dexamethasone attenuates mitochondrial dysfunction in a human inflammatory proximal tubule epithelial cell model. Sci Rep. 2017.

doi: 10.1038/s41598-017-07582-1

[PDF, free access]
E, G, H, J

Mihajlovic M et al. Allostimulatory capacity of conditionally immortalized proximal tubule cell lines for bioartificial kidney application. Scientific Reports. 2017.

[PDF, free access]
G, L

Ivanova EA et al. Ca(2+) signalling in human proximal tubular epithelial cells deficient for cystinosin. Cell Calcium. 2016.

doi: 10.1016/j.ceca.2016.07.001

[Summary only, paid]
G, H, I

Ivanova EA et al. Altered mTOR signalling in nephropathic cystinosis. J Inherit Metab Dis. 2016.

doi: 10.1007/s10545-016-9919-z

[Summary only, paid]
G, H, I

Hulshof F et al. New insights into the effects of biomaterial chemistry and topography on the morphology of kidney epithelial cells. J Tissue Eng Regen Med. 2016.

doi: 10.1002/term.2387

[Summary only, paid]
G, L

Chevtchik et al. Upscaling of a living membrane for bioartificial kidney device. Eur J Pharmacol. 2016.

doi: 10.1016/j.ejphar.2016.07.009

[Summary only, paid]
G, L

Arcolino FO et al. Urine of Preterm Neonates as a Novel Source of Kidney Progenitor Cells. J Am Soc Nephrol.

2016

[PDF, free access]
G, H

van Swelm RP et al. Renal handling of circulating and renal-synthesized hepcidin and its protective effects against hemoglobin-mediated kidney injury. J Am Soc Nephrol. 2016.

doi: 10.1681/ASN.2015040461

[PDF, free access]
G, H

Peters E et al. Alkaline phosphatase protects against renal inflammation through dephosphorylation of lipopolysaccharide and adenosine triphosphate. Br J Pharmacol. 2015.

doi: 10.1152/ajprenal.00352.2014

[PDF, free access]
E, G, H, J

Di Mise A et al. Conditionally Immortalized Human Proximal-Tubular Epithelial Cells isolated from the urine of a healthy subject express functional Calcium Sensing Receptor. Am J Physiol Renal Physiol. 2015.

[PDF, free access]
G, H

Ma L et al. Localization of APOL1 protein and mRNA in the human kidney: nondiseased tissue, primary cells, and immortalized cell lines. J Am Soc Nephrol. 2015.

doi: 10.1681/ASN.2013091017

[PDF, free access]
G

Ivanova EA et al. Endo-Lysosomal Dysfunction in Human Proximal Tubular Epithelial Cells Deficient for Lysosomal Cystine Transporter Cystinosin. PLoS One. 2015.

doi: 10.1371/journal.pone.0120998

[PDF, free access]
G, H, I

Hosper NA et al. Epithelial-to-mesenchymal transition in fibrosis: Collagen type I expression is highly upregulated after EMT, but does not contribute to collagen deposition. Exp Cell Res 2013.

doi: 10.1016/j.yexcr.2013.07.014

[Summary only, paid]
G

Gorvin CM, et al. Receptor-mediated endocytosis and endosomal acidification is impaired in proximal tubule epithelial cells of Dent’s disease patients. Proc Natl Acad Sci2013.

doi: 10.1073/pnas.1302063110

[PDF, free access]
G, H, I

glesias DM et al. Stem cell microvesicles transfer cystinosin to human cystinotic cells and reduce cystine accumulation in vitro. PLoS One. 2012.

doi: 10.1371/journal.pone.0042840

[PDF, free access]
G, H

Mekahli D et al. Polycystin-1 and polycystin-2 are both required to amplify inositol-trisphosphate-induced Ca2+ release. Cell Calcium. 2012.

doi: 10.1016/j.ceca.2012.03.002

[Summary only, paid]
G, H

Vicinanza M et al., OCRL controls trafficking through early endosomes via PtdIns4,5P(2)-dependent regulation of endosomal actin. EMBO J. 2011.

doi: 10.1038/emboj.2011.354

[PDF, free access]
G, H, I

Wilmer MJ et al., Cysteamine restores glutathione redox status in cultured cystinotic proximal tubular epithelial cells. Biochim Biophys Acta 2011.

doi: 10.1016/j.bbadis.2011.02.010

[PDF, free access]
G, H, J

H - Renal Disorders

Mihaila SM. Drugs Commonly Applied to Kidney Patients May Compromise Renal Tubular Uremic Toxins Excretion. 2020 Toxins (Basel).

[PDF, free access]
A, C, E, G, H, K

De Leo E. Cell-Based Phenotypic Drug Screening Identifies Luteolin as Candidate Therapeutic for Nephropathic Cystinosis. 2020. J Am Soc Nephrol. 2020.

doi: 10.1007/s00424-013-1394-x

[Summary only, paid]
D, E, G, H, I

Mekahli D et al. Polycystin-1 but not polycystin-2 deficiency causes upregulation of the mTOR pathway and can be synergistically targeted with rapamycin and metformin. Pflugers Arch. 2014.

[Summary only, paid]
D, E, G, H

Jansen J et al. Remote sensing and signaling in kidney proximal tubules stimulates gut microbiome-derived organic anion secretion. Proc Natl Acad Sci U S A 2019.

[PDF, free access]
A, C, E, G, H, K

Mihajlovic M et al. Role of Vitamin D in Maintaining Renal Epithelial Barrier Function in Uremic Conditions. Int J Mol Sci. 2017.

[PDF, free access]
A, G, H, K

Nieskens TT et al. A Human Renal Proximal Tubule Cell Line with Stable Organic Anion Transporter 1 and 3 Expression Predictive for Antiviral-Induced Toxicity. AAPS J. 2016.

[PDF, free access]
A, B, C, D, E, H

Schophuizen CM et al. Uremic Toxins Induce ET-1 Release by Human Proximal Tubule Cells, which Regulates Organic Cation Uptake Time-Dependently. Cells. 2015.

[PDF, free access]
A, C, G, H, K

Mutsaers HAM et al. Proximal tubular efflux transporters involved in renal excretion of p-cresyl sulfate and p-cresyl glucuronide: Implications for chronic kidney disease pathophysiology. Toxicol In Vitro. 2015.

[Summary only, paid]
A, C, G, H, K

Nieskens TT et al. A Human Renal Proximal Tubule Cell Line with Stable Organic Anion Transporter 1 and 3 Expression Predictive for Antiviral-Induced Toxicity. AAPS J. 2016.

doi: 10.18632/oncotarget.27152

[PDF, free access]
A, B, C, D, E, H

Mihajlovic M. Safety evaluation of conditionally immortalized cells for renal replacement therapy. 2019 Oncotarget.

[PDF, free access]
H, L

van Raaij SEG et al. Iron uptake by ZIP8 and ZIP14 in human proximal tubular epithelial cells. Biometals. 2019.

doi: 10.1007/s10534-019-00183-7

[PDF, free access]
G, H

Bellomo F et al. Impact of atypical mitochondrial cyclic-AMP level in nephropathic cystinosis. Cell Mol Life Sci. 2018.

doi: 10.1007/s00018-018-2800-5

[summary only]
G, H, I

Di Mise A et al. Activation of the Calcium-Sensing Receptor Corrects the Impaired Mitochondrial Energy Status Observed in Renal Polycystin-1 Knockdown Cells Modeling Autosomal Dominant Polycystic Kidney Disease. Front Mol Biosci. 2018.

doi: 10.3389/fmolb.2018.00077

[PDF, free access]
G, H, J

Raaij, van SEG et al. Inhibition of Nrf2 alters cell stress induced by chronic iron exposure in human proximal tubular epithelial cells. Toxicol Lett. 2018.

doi: 10.1016/j.toxlet.2018.06.1218

[Summary only, paid]
G, H, J

Di Mise A et al. Activation of Calcium-Sensing Receptor increases intracellular calcium and decreases cAMP and mTOR in PKD1 deficient cells. Sci Rep. 2018.

doi: 10.1038/s41598-018-23732-5

[PDF, free access]
G, H

Jamalpoor A et al. Quantification of cystine in human renal proximal tubule cells using liquid chromatography-tandem mass spectrometry. Biomed Chromatogr. 2018.

doi: 10.1002/bmc.4238

[PDF, free access]
G, H, I

Weber HM et al. Heparin-based hydrogels induce human renal tubulogenesis in vitro. Acta Biomater. 2017.

doi: 10.1016/j.actbio.2017.05.035

[Summary only, paid]
G, H, L

Schirris TJJet al. Mild intracellular acidification by dexamethasone attenuates mitochondrial dysfunction in a human inflammatory proximal tubule epithelial cell model. Sci Rep. 2017.

doi: 10.1016/j.ceca.2016.07.001

[PDF, free access]
E, G, H, J

Ivanova EA et al. Ca(2+) signalling in human proximal tubular epithelial cells deficient for cystinosin. Cell Calcium. 2016.

[Summary only, paid]
G, H, I

Ivanova EA et al. Altered mTOR signalling in nephropathic cystinosis. J Inherit Metab Dis. 2016.

doi: 10.1007/s10545-016-9919-z

[Summary only, paid]
G, H, I

Arcolino FO et al. Urine of Preterm Neonates as a Novel Source of Kidney Progenitor Cells. J Am Soc Nephrol.

2016

[PDF, free access]
G, H

van Swelm RP et al. Renal handling of circulating and renal-synthesized hepcidin and its protective effects against hemoglobin-mediated kidney injury. J Am Soc Nephrol. 2016.

doi: 10.1681/ASN.2015040461

[PDF, free access]
G, H

Peters E et al. Alkaline phosphatase protects against renal inflammation through dephosphorylation of lipopolysaccharide and adenosine triphosphate. Br J Pharmacol. 2015.

doi: 10.1152/ajprenal.00352.2014

[PDF, free access]
E, G, H, J

Di Mise A et al. Conditionally Immortalized Human Proximal-Tubular Epithelial Cells isolated from the urine of a healthy subject express functional Calcium Sensing Receptor. Am J Physiol Renal Physiol. 2015.

[PDF, free access]
G, H

Ivanova EA et al. Endo-Lysosomal Dysfunction in Human Proximal Tubular Epithelial Cells Deficient for Lysosomal Cystine Transporter Cystinosin. PLoS One. 2015.

doi: 10.1371/journal.pone.0120998

[PDF, free access]
G, H, I

Gorvin CM, et al. Receptor-mediated endocytosis and endosomal acidification is impaired in proximal tubule epithelial cells of Dent’s disease patients. Proc Natl Acad Sci2013.

doi: 10.1073/pnas.1302063110

[PDF, free access]
G, H, I

glesias DM et al. Stem cell microvesicles transfer cystinosin to human cystinotic cells and reduce cystine accumulation in vitro. PLoS One. 2012.

doi: 10.1371/journal.pone.0042840

[PDF, free access]
G, H

Mekahli D et al. Polycystin-1 and polycystin-2 are both required to amplify inositol-trisphosphate-induced Ca2+ release. Cell Calcium. 2012.

doi: 10.1016/j.ceca.2012.03.002

[Summary only, paid]
G, H

Vicinanza M et al., OCRL controls trafficking through early endosomes via PtdIns4,5P(2)-dependent regulation of endosomal actin. EMBO J. 2011.

doi: 10.1038/emboj.2011.354

[PDF, free access]
G, H, I

Wilmer MJ et al., Cysteamine restores glutathione redox status in cultured cystinotic proximal tubular epithelial cells. Biochim Biophys Acta 2011.

doi: 10.1016/j.bbadis.2011.02.010

[PDF, free access]
G, H, J

I - Endocytosis

De Leo E. Cell-Based Phenotypic Drug Screening Identifies Luteolin as Candidate Therapeutic for Nephropathic Cystinosis. 2020. J Am Soc Nephrol. 2020.

[Summary only, paid]
D, E, G, H, I

Janssen MJ et al. Therapy with 2′-O-Me Phosphorothioate Antisense Oligonucleotides Causes Reversible Proteinuria by Inhibiting Renal Protein Reabsorption. Mol Ther Nucleic Acids. 2019.

doi: 10.1161/HYPERTENSIONAHA.120.14845

[PDF, free access]
A, B, D, E, I

Sun Y. Megalin: A Novel Endocytic Receptor for Prorenin and Renin. 2020 Hypertension.

[PDF, free access]
E, G, I

Bellomo F et al. Impact of atypical mitochondrial cyclic-AMP level in nephropathic cystinosis. Cell Mol Life Sci. 2018.

doi: 10.1007/s00018-018-2800-5

[Summary only, paid]
G, H, I

Jamalpoor A et al. Quantification of cystine in human renal proximal tubule cells using liquid chromatography-tandem mass spectrometry. Biomed Chromatogr. 2018.

doi: 10.1002/bmc.4238

[PDF, free access]
G, H, I

Ivanova EA et al. Ca(2+) signalling in human proximal tubular epithelial cells deficient for cystinosin. Cell Calcium. 2016.

doi: 10.1016/j.ceca.2016.07.001

[Summary only, paid]
G, H, I

Ivanova EA et al. Altered mTOR signalling in nephropathic cystinosis. J Inherit Metab Dis. 2016.

doi: 10.1007/s10545-016-9919-z

[Summary only, paid]
G, H, I

Ivanova EA et al. Endo-Lysosomal Dysfunction in Human Proximal Tubular Epithelial Cells Deficient for Lysosomal Cystine Transporter Cystinosin. PLoS One. 2015.

doi: 10.1371/journal.pone.0120998

[PDF, free access]
G, H, I

Gorvin CM, et al. Receptor-mediated endocytosis and endosomal acidification is impaired in proximal tubule epithelial cells of Dent’s disease patients. Proc Natl Acad Sci2013.

doi: 10.1073/pnas.1302063110

[PDF, free access]
G, H, I

Vicinanza M et al., OCRL controls trafficking through early endosomes via PtdIns4,5P(2)-dependent regulation of endosomal actin. EMBO J. 2011.

doi: 10.1038/emboj.2011.354

[PDF, free access]
G, H, I

J - Metabolism

Mutsaers H et al. Uremic toxins inhibit renal metabolic capacity through interference with glucuronidation and mitochondrial respiration. Biochim Biophys Acta 2013.

doi: 10.1016/j.bbadis.2012.09.006

[PDF, free access]
C, G, J, K

Vriend J. Organic anion transporters 1 and 3 influence cellular energy metabolism in renal proximal tubule cells. 2019 Biol Chem.

doi: 10.1515/hsz-2018-0446

[Summary only, paid]
A, G, J

Vriend J et al. Organic anion transporters 1 and 3 influence cellular energy metabolism in renal proximal tubule cells. Biol Chem. 2019.

doi: 10.1007/s10637-020-00970-x

[Summary only, paid]
A, C, G, J

Rood JJM. Extrahepatic metabolism of ibrutinib. 2020 Invest New Drugs.

[PDF, free access]
E, G, J

Di Mise A et al. Activation of the Calcium-Sensing Receptor Corrects the Impaired Mitochondrial Energy Status Observed in Renal Polycystin-1 Knockdown Cells Modeling Autosomal Dominant Polycystic Kidney Disease. Front Mol Biosci. 2018.

doi: 10.3389/fmolb.2018.00077

[PDF, free access]
G, H, J

Raaij, van SEG et al. Inhibition of Nrf2 alters cell stress induced by chronic iron exposure in human proximal tubular epithelial cells. Toxicol Lett. 2018.

doi: 10.1016/j.toxlet.2018.06.1218

[Summary only, paid]
G, H, J

Schirris TJJet al. Mild intracellular acidification by dexamethasone attenuates mitochondrial dysfunction in a human inflammatory proximal tubule epithelial cell model. Sci Rep. 2017.

doi:10.1016/j.ejphar.2016.12.034

[PDF, free access]
E, G, H, J

Peters E et al. Effects of a human recombinant alkaline phosphatase during impaired mitochondrial function in human renal proximal tubule epithelial cells. Eur J Pharmacol. 2017.

[Summary only, paid]
E, J

Peters E et al. Alkaline phosphatase protects against renal inflammation through dephosphorylation of lipopolysaccharide and adenosine triphosphate. Br J Pharmacol. 2015.

doi: 10.1016/j.bbadis.2011.02.010

[PDF, free access]
E, G, H, J

Wilmer MJ et al., Cysteamine restores glutathione redox status in cultured cystinotic proximal tubular epithelial cells. Biochim Biophys Acta 2011.

[PDF, free access]
G, H, J

K - Uremic Toxins

Mihaila SM. Drugs Commonly Applied to Kidney Patients May Compromise Renal Tubular Uremic Toxins Excretion. 2020 Toxins (Basel).

[PDF, free access]
A, C, E, G, H, K

Mutsaers H et al. Uremic toxins inhibit renal metabolic capacity through interference with glucuronidation and mitochondrial respiration. Biochim Biophys Acta 2013.

doi: 10.1016/j.bbadis.2012.09.006

[PDF, free access]
C, G, J, K

Van der Made TK et al. Quantitative Translation of Microfluidic Transporter in Vitro Data to in Vivo Reveals Impaired Albumin-Facilitated Indoxyl Sulfate Secretion in Chronic Kidney Disease. 2019 Mol Pharm.

[Summary only, paid]
A, B, E, G, K

Jansen J et al. Remote sensing and signaling in kidney proximal tubules stimulates gut microbiome-derived organic anion secretion. Proc Natl Acad Sci U S A 2019.

[PDF, free access]
A, C, E, G, H, K

Mihajlovic M et al. Role of Vitamin D in Maintaining Renal Epithelial Barrier Function in Uremic Conditions. Int J Mol Sci. 2017.

[PDF, free access]
A, G, H, K

Jansen J et al. Bioengineered kidney tubules efficiently excrete uremic toxins. Scientific Reports. Sci Rep. 2016.

[PDF, free access]
A, C, F, K, L

Schophuizen CM et al. Uremic Toxins Induce ET-1 Release by Human Proximal Tubule Cells, which Regulates Organic Cation Uptake Time-Dependently. Cells. 2015.

[PDF, free access]
A, C, G, H, K

Jansen J. et al. Human proximal tubule epithelial cells cultured on hollow fibers: living membranes that actively transport organic cations. Sci Rep. 2015.

[PDF, free access]
A, C, F, K, L

Mutsaers HAM et al. Proximal tubular efflux transporters involved in renal excretion of p-cresyl sulfate and p-cresyl glucuronide: Implications for chronic kidney disease pathophysiology. Toxicol In Vitro. 2015.

[Summary only, paid]
A, C, G, H, K

Schophuizen CMS et al. Cationic uremic toxins affect renal proximal tubule cell functioning through interaction with the organic cation transporter (hOCT2). Pflügers Archives 2013.

doi: 10.3389/fbioe.2020.617364

[Summary only, paid]
A, C, G, K

L - Renal Replacement therapy and artificial kidney

van Genderen AM .Topographic Guidance in Melt-Electrowritten Tubular Scaffolds Enhances Engineered Kidney Tubule Performance. 2021 Front Bioeng Biotechnol.

[PDF, free access]
C, L

Jansen J et al. Bioengineered kidney tubules efficiently excrete uremic toxins. Scientific Reports. Sci Rep. 2016.

[PDF, free access]
A, C, F, K, L

Jansen J. et al. Human proximal tubule epithelial cells cultured on hollow fibers: living membranes that actively transport organic cations. Sci Rep. 2015.